Author

Srinivas N. Puttapaka

Beth Israel Deaconess Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Approach:experimental assay· 3 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Subhash KulkarniiD· 5 shared Jared SlosbergiD· 4 shared Philippa SeikaiD· 4 shared Su Min HongiD· 4 shared Ainsleigh Scott· 3 shared Alpana SinghiD· 2 shared Gamze SönmeziD· 2 shared Alan ConsortiiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersNeuroscience

Subhash KulkarniORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proteome wide serology reveals immune defined subtypes of gastrointestinal disease in systemic sclerosis

Zsuzsanna Hortobagyi McMahan, Srinivas N. Puttapaka, Tyler W. Hulett, Ami A. Shah, Kathyrn Faheem, Shaohui Hu, Gamze Sönmez, Pedro Luis Ramos, Subhash Kulkarni

This study identifies immune-defined subtypes of gastrointestinal disease in systemic sclerosis using proteome-wide serology, revealing distinct autoantibody profiles and clinically meaningful disease phenotypes.

bioRxiv · May 21, 2026 · PreprintImmunology

Enteric neurons modulate colorectal cancer cell cycle through a PCSK1 - Methionine-Enkephalin Axis

Philippa Seika, Srinivas N. Puttapaka, Su Min Hong, Ainsleigh Scott, Jared Slosberg, Stefânia Bovo Minto, Kevin M. Haigis, Subhash Kulkarni

This study identifies a neuronal PCSK1-M-ENK pathway in the ENS that suppresses colorectal cancer growth through OGFr activation.

bioRxiv · May 6, 2026 · PreprintCancer Biology

Reduced enteric Bdnf expression and TrkB-dependent regulation of Vip in a Mecp2-null mouse model of Rett syndrome-associated gastrointestinal dysmotility

Srinivas N. Puttapaka, Israel Abebe Admasu, Ainsleigh Scott, Gamze Sönmez, Philippa Seika, Mahalakshmi Rajkumar, Xavier Valencia, Alan Consorti, Su Min Hong, Jared Slosberg, Michela Fagiolini, Subhash Kulkarni

This study identifies reduced enteric Bdnf and altered VIPergic signaling as key mechanisms of GI dysmotility in a Mecp2-null mouse model of Rett syndrome.

bioRxiv · Apr 15, 2026 · PreprintNeuroscience

Detection of mitotic neuroblasts provides additional evidence of steady state neurogenesis in the adult small intestinal myenteric plexus

Anastazja M. Gorecki, Jared Slosberg, Su Min Hong, Philippa Seika, Srinivas N. Puttapaka, Blake Migden, Anton Gulko, Alpana Singh, Chengxiu Zhang, Rohin Gurumurthy, Subhash Kulkarni

The paper detects mitotic neuroblasts in adult murine and human small intestinal myenteric plexus, providing evidence of steady-state neurogenesis.

eNeuro · Feb 11, 2025Peer-reviewedNeuroscience

Reduced enteric BDNF-TrkB signaling drives stress-dependent glucocorticoid-mediated GI dysmotility

Jared Slosberg, Srinivas N. Puttapaka, Philippa Seika, Su Min Hong, Alpana Singh, Ainsleigh Scott, Subhash Kulkarni

This study shows stress-induced glucocorticoid signaling reduces BDNF-TrkB signaling in the enteric nervous system, leading to GI dysmotility, and identifies TrkB as a potential therapeutic target.

bioRxiv · Dec 13, 2024 · PreprintNeuroscience