Jared Slosberg

This study identifies a neuronal PCSK1-M-ENK pathway in the ENS that suppresses colorectal cancer growth through OGFr activation.

This study identifies reduced enteric Bdnf and altered VIPergic signaling as key mechanisms of GI dysmotility in a Mecp2-null mouse model of Rett syndrome.

The paper detects mitotic neuroblasts in adult murine and human small intestinal myenteric plexus, providing evidence of steady-state neurogenesis.

This study shows stress-induced glucocorticoid signaling reduces BDNF-TrkB signaling in the enteric nervous system, leading to GI dysmotility, and identifies TrkB as a potential therapeutic target.

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.

The paper introduces tricycle, a method to predict cell cycle position from single-cell RNA-seq data using transfer learning, showing it generalizes across datasets and species.

The paper introduces scProject and projectionDrivers to identify gene-wise differences in latent space projections across cell types and species in single-cell data, validated on mouse and human retinal development.