BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
Pei Xin Lim, Mahdia Zaman, Weiran Feng, Maria Jasin
The paper shows BRCA2 stabilizes RAD51 filaments for fork protection and gap suppression, but HDR deficiency primarily drives chemotherapeutic sensitivity.
Molecular Cell · Jan 19, 2024Peer-reviewedMolecular Biology