Author

Weiran Feng

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-3422-4964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Maria JasiniD· 2 shared Ari J. FirestoneiD· 1 shared Caitlin Baxter· 1 shared Charles L. SawyersiD· 1 shared Chen Khuan WongiD· 1 shared D. Henry Kates· 1 shared Diana Zakharova· 1 shared Hojin Lee· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Maria JasinORCID

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3 papers

Recent·Most cited

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening

Samir Zaidi, Maren Büttner, Weiran Feng, Caitlin Baxter, D. Henry Kates, Tiago Paiva Prudente, Diana Zakharova, Sanjoy Mehta, Subhiksha Nandakumar, Chen Khuan Wong, Hojin Lee, Pierre-Jacques Hamard, Wenfei Kang, Jungmin Choi, Ronan Chaligne, , Charles L. Sawyers

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

bioRxiv · May 8, 2026 · PreprintCancer Biology

BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair

Pei Xin Lim, Mahdia Zaman, Weiran Feng, Maria Jasin

The paper shows BRCA2 stabilizes RAD51 filaments for fork protection and gap suppression, but HDR deficiency primarily drives chemotherapeutic sensitivity.

Molecular Cell · Jan 19, 2024Peer-reviewedMolecular Biology

53BP1 nuclear body-marked replication stress in a human mammary cell model of BRCA2 deficiency

Weiran Feng, Maria Jasin

The paper investigates replication stress and 53BP1 nuclear body formation in BRCA2-deficient human mammary cells, showing their link to G1 arrest and genome instability.

bioRxiv · Nov 5, 2018 · PreprintMolecular Biology