The SMARCA5-DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development
Yuka Kitamura, Yasuhisa Munakata, Hironori Abe, Mengwen Hu, Satoyo Oya, Shanmathi Murugesan, Mahnoor Rizwan, Shawna P. Katz, David J. Picketts, Richard M. Schultz, Satoshi H. Namekawa
This study shows that SMARCA5 and DMRT1 form a pioneer complex that establishes epigenetic priming necessary for male germline differentiation in response to retinoic acid.
bioRxiv · Jul 29, 2025 · PreprintDevelopmental Biology