David J. Picketts

Molecular dissection of the ChAHP complex subunits Adnp and Chd4 reveals common and divergent functions in retinal development

This study investigates the role of the ChAHP complex in retinal development by analyzing Adnp and Chd4 knockouts, revealing shared and distinct functions in cell proliferation and fate.

An allelic series reveals the genetic requirement for Adnp in cortical neurogenesis and learning behavior

This study investigates the role of Adnp in cortical neurogenesis and learning behavior through allelic series analysis, finding that Adnp dosage affects cortical growth and learning, with similar phenotypes across different mutant models.

ISWI remodeler facilitates cBAF genomic binding to drive cell fate transition

This study shows ISWI remodelers are essential for muscle and adipose development and link LDTF binding to cBAF recruitment during cell fate transition.

The SMARCA5-DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

This study shows that SMARCA5 and DMRT1 form a pioneer complex that establishes epigenetic priming necessary for male germline differentiation in response to retinoic acid.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers

The paper shows that the ChAHP complex regulates upper-layer neuron production and NDD risk genes during neocortical development through progenitor proliferation and gene regulation.

A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects

This paper introduces a knock-in mouse model of ATR-X syndrome carrying a common patient mutation, showing craniofacial defects, microcephaly, and impaired neurological function.