Yasuhisa Munakata

The paper shows that paternal folate deficiency affects meiotic chromatin and epigenomic changes in the male germline, particularly at CGI-associated promoters.

The paper shows Polycomb complexes regulate active chromatin remodeling during ovarian reserve formation and oocyte growth, establishing quiescence and future promoter states through distinct H3K27ac and H3K4me3 dynamics.

The paper identifies newly evolved endogenous retroviruses (ERVs) as drivers of epigenetic priming in non-growing oocytes, enabling follicular activation during oogenesis.

This study shows that SMARCA5 and DMRT1 form a pioneer complex that establishes epigenetic priming necessary for male germline differentiation in response to retinoic acid.

This study shows that non-growing oocytes in mice have pre-established epigenetic marks that prime the epigenome for oocyte maturation and early embryogenesis, challenging the traditional view that these marks are acquired after ovarian reserve exit.

This study identifies ATF7IP2 as a critical regulator of H3K9 methylation and meiotic gene regulation in male germline, showing its role in heterochromatin organization and meiotic sex chromosome inactivation.

This study shows that CTCF-mediated 3D chromatin structure pre-establishes gene expression programs required for spermatogenesis by forming meiosis-specific super-enhancers and regulating chromatin loops.