Richard M. Schultz

This study shows culturing mouse embryos at 2% oxygen improves embryonic and adult outcomes compared to 5% oxygen, by enhancing cell number, chromatin structure, and metabolic function.

The paper shows that paternal folate deficiency affects meiotic chromatin and epigenomic changes in the male germline, particularly at CGI-associated promoters.

The paper shows Polycomb complexes regulate active chromatin remodeling during ovarian reserve formation and oocyte growth, establishing quiescence and future promoter states through distinct H3K27ac and H3K4me3 dynamics.

The paper identifies newly evolved endogenous retroviruses (ERVs) as drivers of epigenetic priming in non-growing oocytes, enabling follicular activation during oogenesis.

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.

This study shows that SMARCA5 and DMRT1 form a pioneer complex that establishes epigenetic priming necessary for male germline differentiation in response to retinoic acid.

This study shows that non-growing oocytes in mice have pre-established epigenetic marks that prime the epigenome for oocyte maturation and early embryogenesis, challenging the traditional view that these marks are acquired after ovarian reserve exit.

This study shows that IVF in mice leads to reproductive and molecular changes in male offspring, which are transmitted across generations.

This study shows that KRAB-zinc-finger proteins regulate endogenous retroviruses in the germline, shaping transcriptomes and genome evolution through evolutionary conserved mechanisms.

This study identifies CHK1's role in regulating cell cycle progression in early mouse embryos to maintain genome integrity and prevent aneuploidy.

This study profiles histone modifications during bovine preimplantation development, showing their role in gene regulation and lineage specification.

This study examines sex-specific metabolic and transcriptomic effects of IVF in mice, finding sex-dimorphic dysregulation of SREBP pathways and placental DNA methylation changes linked to cholesterol levels.

The paper profiles accessible chromatin in bovine embryos to show species-specific regulation of genome activation, finding similarities between cattle and humans but differences from mice.

This study shows that Cnot6l is essential for maternal mRNA turnover during oocyte-to-embryo transition in mice, with loss of Cnot6l leading to reduced litter size and developmental arrest.