Structural basis of stereochemical promiscuity by an umami taste receptor ortholog, Tas1r1/Tas1r3 from pufferfish
Rakuto Mizoguchi, Yasuka Toda, Mana Nagae, Takashi Yoshida, Hiroaki Matsuura, Kunio Hirata, Yohei Miyanoiri, Maiko Hosotani, Yuji Ashikawa, Chiaki Ito, Naotaka Tsutsumi, N. Yasui, Yoshiro Ishimaru, Atsuko Yamashita
This study determines the crystal structure of a pufferfish umami taste receptor ortholog, revealing how it binds both L- and D-amino acids through structural adaptations.
bioRxiv · Nov 24, 2025 · PreprintBiochemistry