Kunio Hirata

Structural basis of stereochemical promiscuity by an umami taste receptor ortholog, Tas1r1/Tas1r3 from pufferfish

This study determines the crystal structure of a pufferfish umami taste receptor ortholog, revealing how it binds both L- and D-amino acids through structural adaptations.

Cell-Free Protein Crystallization Enables Rapid Structure Determination of Disaccharides and Trisaccharides Using Galectin-10 Crystals

This study uses cell-free protein crystallization to determine atomic structures of saccharides bound to galectin-10, revealing binding modes not accessible by conventional methods.

Elucidating polymorphs of crystal structures with intensity-based hierarchical clustering analysis on multiple diffraction datasets

This paper demonstrates the use of intensity-based hierarchical clustering to detect structural polymorphs in diffraction datasets from multiple crystals.

X-ray structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

The paper reports X-ray structures of the human ETB receptor bound to agonists, revealing molecular mechanisms of activation and partial agonism.