Temperature sensitive SMA-causing point mutations lead to SMN instability, locomotor defects, and premature lethality in Drosophila
Amanda C. Raimer, Suhana S. Singh, Maina R. Edula, Tamara Paris‐Davila, Vasudha Vandadi, Ashlyn M. Spring, A. Gregory Matera
This paper shows that temperature-sensitive SMA-causing mutations in Drosophila SMN lead to SMN instability, locomotor defects, and premature death, highlighting SMN's role in development.
Disease Models & Mechanisms · Jan 1, 2020Peer-reviewedGenetics