A. Gregory Matera

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

The paper investigates the role of Set2 and H3K36 in Drosophila dosage compensation, finding that their effects are context-dependent and not directly linked to MSL complex recruitment.

The paper identifies SMN complex binding partners and reveals conserved connections to chaperone systems, linking chaperone dysfunction to ALS and SMA.

The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

This study identifies hyperactivation of innate immune signaling as a consequence of SMN depletion in Drosophila SMA models, revealing a conserved regulatory role of the SMN complex.

This study shows that mutating lysine-36 of Drosophila histone H3.3 reduces adult lifespan and disrupts genomic and transcriptomic stability.

The paper shows that reduced canonical histone gene copy number in Drosophila disrupts Polycomb function, leading to developmental defects and ectopic sex combs.

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

This study shows that Set8/KMT5A and H4K20me1 have distinct roles in Drosophila development, with non-catalytic functions of Set8 and H4K20me1 contributing to viability and phenotypic differences.

This study shows that mutations in Drosophila tRNA processing factors cause phenotypes similar to human Pontocerebellar Hypoplasia, including reduced brain size and motor dysfunction.

This study reconstitutes the human tRNA splicing endonuclease complex and shows that CLP1 is not required for tRNA intron cleavage but may regulate tRNA splicing as a negative modulator.

This paper shows that temperature-sensitive SMA-causing mutations in Drosophila SMN lead to SMN instability, locomotor defects, and premature death, highlighting SMN's role in development.

This study models spinal muscular atrophy in Drosophila using patient-derived missense mutations, showing similar phenotypes to human SMA across multiple adult neuromuscular metrics.

The paper identifies cis- and trans-acting factors involved in tricRNA biogenesis in Drosophila and human cells.

The paper identifies CG2941 as a Gemin4 ortholog in Drosophila melanogaster and shows its essential role in organismal viability.

The paper uses high-depth TSS mapping in D. melanogaster to identify novel initiation events and characterize enhancer-associated RNAs (eRNAs) in a developmental context.

The paper investigates the functional roles of K9 modifications on variant and canonical histone H3 in Drosophila, showing overlapping but distinct contributions to chromatin structure and gene regulation.

This study replaces H3K36 with arginine in Drosophila to show H3K36 methylation maintains transcriptome fidelity through post-transcriptional mechanisms involving polyadenylation.

This study compares transcriptomic changes in Drosophila snRNP biogenesis mutants to identify snRNP-dependent and Smn-specific RNA processing defects, finding differences between hypomorphic and complete loss-of-function Smn mutants.