Author

Vasudha Vandadi

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Gregory MateraiD· 5 shared Harmony R. SalzleriD· 4 shared Benjamin D. McMichaeliD· 2 shared John C. BrowniD· 2 shared Aadit MukherjeeiD· 1 shared Alexis K Hirth· 1 shared Amanda C. Raimer· 1 shared Apoorva BaluapuriiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersGenetics

A. Gregory MateraORCID

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5 papers

Recent·Most cited

Nascent transcription profiling identifies H3K36 methylation as a custodian of the somatic transcriptome

Hina Sultana, Vasudha Vandadi, Harmony R. Salzler, Apoorva Baluapuri, Darshan Ponkiya, Alexis K Hirth, Grace C Vernesoni, Seth Raphael Goldman, Karen Adelman, A. Gregory Matera

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

bioRxiv · Oct 28, 2026 · PreprintGenetics

Set2 and H3K36 regulate the Drosophila male X chromosome in a context-specific manner, independent from MSL complex spreading

Harmony R. Salzler, Vasudha Vandadi, Julia R Sallean, A. Gregory Matera

The paper investigates the role of Set2 and H3K36 in Drosophila dosage compensation, finding that their effects are context-dependent and not directly linked to MSL complex recruitment.

Genetics · Oct 17, 2024Peer-reviewedGenomics

Lysine-36 of Drosophila histone H3.3 supports adult longevity

John C. Brown, Benjamin D. McMichael, Vasudha Vandadi, Aadit Mukherjee, Harmony R. Salzler, A. Gregory Matera

This study shows that mutating lysine-36 of Drosophila histone H3.3 reduces adult lifespan and disrupts genomic and transcriptomic stability.

bioRxiv · Sep 28, 2023 · PreprintGenetics

Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

Harmony R. Salzler, Vasudha Vandadi, Benjamin D. McMichael, John C. Brown, Sally A. Boerma, Mary P Leatham-Jensen, Kirsten M. Adams, Michael P. Meers, Jeremy M. Simon, Robert J. Duronio, Daniel J. McKay, A. Gregory Matera

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

Science Advances · Mar 1, 2023Peer-reviewedGenomics

Temperature sensitive SMA-causing point mutations lead to SMN instability, locomotor defects, and premature lethality in Drosophila

Amanda C. Raimer, Suhana S. Singh, Maina R. Edula, Tamara Paris‐Davila, Vasudha Vandadi, Ashlyn M. Spring, A. Gregory Matera

This paper shows that temperature-sensitive SMA-causing mutations in Drosophila SMN lead to SMN instability, locomotor defects, and premature death, highlighting SMN's role in development.

Disease Models & Mechanisms · Jan 1, 2020Peer-reviewedGenetics