Reconstitution of the Human tRNA Splicing Endonuclease Complex: insight into the regulation of pre-tRNA cleavage.
Cassandra K. Hayne, Casey A. Schmidt, Maira I Haque, A. Gregory Matera, Robin Evans Stanley
This study reconstitutes the human tRNA splicing endonuclease complex and shows that CLP1 is not required for tRNA intron cleavage but may regulate tRNA splicing as a negative modulator.
Nucleic Acids Research · May 13, 2020Peer-reviewedMolecular Biology