Author

Cassandra K. Hayne

National Institute of Environmental Health SciencesORCID 0000-0002-2485-5949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Gregory MateraiD· 1 shared Casey A. SchmidtiD· 1 shared Lizette ZavalaiD· 1 shared Magdalena SobieńiD· 1 shared Maira I Haque· 1 shared Robin Evans StanleyiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperMolecular Biology

A. Gregory MateraORCID

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2 papers

Recent·Most cited

Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization.

Lizette Zavala, Magdalena Sobień, Cassandra K. Hayne

This study investigates how PCH7-linked TOE1 mutations affect thermal stability, ribonuclease activity, and oligomerization, revealing their impact on TOE1 biochemistry.

Journal of Biological Chemistry · May 24, 2026Peer-reviewedBiochemistry

Reconstitution of the Human tRNA Splicing Endonuclease Complex: insight into the regulation of pre-tRNA cleavage.

Cassandra K. Hayne, Casey A. Schmidt, Maira I Haque, A. Gregory Matera, Robin Evans Stanley

This study reconstitutes the human tRNA splicing endonuclease complex and shows that CLP1 is not required for tRNA intron cleavage but may regulate tRNA splicing as a negative modulator.

Nucleic Acids Research · May 13, 2020Peer-reviewedMolecular Biology