Intradental mechano-nociceptors serve as sentinels that prevent tooth damage
Elizabeth A. Ronan, Akash R. Gandhi, Karin Harumi Uchima Koecklin, Yujia Hu, Shuhao Wan, Brian S.C. Constantinescu, Mak E. Guenther, Maximilian Nagel, L. Liu, Aditi Jha, Leen Dakhilalla, Kaitlyn J. Blumberg, Isaac T Berthaume, Tomer Stern, Kevin Patrick Pipe, , Joshua J. Emrick
This study identifies intradental high-threshold mechano-nociceptors that detect tooth damage, produce pain, and trigger protective reflexes.
Cell Reports · Jul 16, 2025Peer-reviewedNeuroscience