Bing Ye

LabGrymace automates pain assessment in mice by analyzing facial dynamics from video, providing continuous pain scores across different pain types.

The paper introduces LabGym, an open-source AI platform for automated analysis of C. elegans locomotion behavior in multi-worm videos with high accuracy.

The paper investigates neurotype matching in prairie voles by manipulating early-life sleep experience and uses deep learning to analyze social interactions.

This study identifies intradental high-threshold mechano-nociceptors that detect tooth damage, produce pain, and trigger protective reflexes.

The paper improves the FLARE system to better record and manipulate neuronal activity by enhancing calcium sensitivity and signal-to-background ratio in Drosophila models.

This study shows that DSCAM heterozygosity in mice produces autistic-like behaviors, supporting its role in ASD and suggesting it as a model for research.

This paper introduces a subject-aware deep-learning system to quantify social roles in multi-animal groups across species and assays.

This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

The paper develops improved genetically-encoded cAMP sensors, cAMPFIREs, for high-sensitivity in vivo imaging of cAMP dynamics in neurons and Drosophila.

The paper introduces isoTarget, a genetic method to block specific splicing isoforms and tag them for analysis, revealing their distinct roles in neuronal development.

This study shows that a frameshift mutation in YPEL3 in Drosophila reduces nociceptive responses by impairing synaptic connections between nociceptors and second-order neurons.

This study introduces Lineage Tracker Bitbow, a multi-spectral lineage tracing system for Drosophila, and uses it to map neuronal lineages and analyze cis-regulatory elements in lineage-specific gene expression.