LSm4 biomolecular condensates drive XRN2-mediated RNA decay at DNA double-strand breaks to facilitate repair
Malak M. Darawshe, Laila A. Bishara, Enas R. Abu‐Zhayia, Alma Sophia Barisaac, Feras E. Machour, Christeen Elmor, Nabieh Ayoub
This study identifies LSm4 biomolecular condensates as key regulators of RNA decay at DNA double-strand breaks, preventing R-loop accumulation and enabling efficient repair.
bioRxiv · Aug 20, 2026 · PreprintMolecular Biology