Nabieh Ayoub

LSm4 biomolecular condensates drive XRN2-mediated RNA decay at DNA double-strand breaks to facilitate repair

This study identifies LSm4 biomolecular condensates as key regulators of RNA decay at DNA double-strand breaks, preventing R-loop accumulation and enabling efficient repair.

SLAYER: A Computational Framework for Identifying Synthetic Lethal Interactions through Integrated Analysis of Cancer Dependencies

SLAYER identifies synthetic lethal interactions by integrating cancer genomic data and CRISPR screens, finding 142 high-confidence candidates with 15-fold enrichment over random pairs.

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

This study identifies RBM10's role in DNA replication and shows that targeting WEE1 can sensitize RBM10-deficient lung adenocarcinoma cells.

Systematic identification of a CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

The paper identifies CDYL1-dependent reduction in lysine crotonylation at DSBs, showing transcriptional silencing and repair are functionally uncoupled.