Alzheimer's Disease and circadian disruption sex-specifically contribute to a loss of bone maintenance in APP/PS1 model mice
Noah G. Allen, Carmalena V. Cordi, Joan E. LLabre, Joshua Chuah, Gretchen T. Clark, Angela J. Kubik, Naomi G. Falkenberg, Meaghan S. Jankowski, Rukmani A Cahill, Ava A. Herzog, Mallika Subash Chander, Deepak Vashishth, Jennifer Hurley, Elizabeth A. Blaber
This study shows that Alzheimer's disease and circadian disruption sex- and genotype-specifically reduce bone maintenance in APP/PS1 mice by affecting marrow progenitors and macrophages.
bioRxiv · May 5, 2026 · PreprintBioengineering