Meaghan S. Jankowski

Proteoform plasticity modulates the temperature response in circadian timekeeping

This study investigates how alternative splicing of intrinsically disordered regions in the fungal circadian protein FRQ affects temperature-dependent clock function.

Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages

This study investigates how circadian rhythms affect macrophage responses to SARS-CoV-2 spike proteins, finding that timing of exposure leads to distinct immunometabolic states.

Circadian disruption induces sex-specific Alzheimer's pathophysiology and immune cell reprogramming

This study shows circadian disruption causes sex-specific changes in Alzheimer's pathology and immune cell behavior in mice.

Alzheimer's Disease and circadian disruption sex-specifically contribute to a loss of bone maintenance in APP/PS1 model mice

This study shows that Alzheimer's disease and circadian disruption sex- and genotype-specifically reduce bone maintenance in APP/PS1 mice by affecting marrow progenitors and macrophages.

Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress

This study investigates how chronic short sleep affects metabolism and survival under oxidative stress in mutants, finding common metabolic defects and suggesting lipid metabolism issues may underlie oxidative stress sensitivity.

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock.

The paper identifies a fuzzy complex formed by negative-arm proteins that regulates the robustness of the circadian clock through electrostatic interactions and conserved motifs.

ECHO: an Application for Detection and Analysis of Oscillators Identifies Metabolic Regulation on Genome-Wide Circadian Output

ECHO detects and analyzes oscillators in time-course genome-scale data, revealing metabolic regulation through circadian rhythms with changing amplitudes.