Jennifer Hurley

Proteoform plasticity modulates the temperature response in circadian timekeeping

This study investigates how alternative splicing of intrinsically disordered regions in the fungal circadian protein FRQ affects temperature-dependent clock function.

Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages

This study investigates how circadian rhythms affect macrophage responses to SARS-CoV-2 spike proteins, finding that timing of exposure leads to distinct immunometabolic states.

Circadian disruption induces sex-specific Alzheimer's pathophysiology and immune cell reprogramming

This study shows circadian disruption causes sex-specific changes in Alzheimer's pathology and immune cell behavior in mice.

Alzheimer's Disease and circadian disruption sex-specifically contribute to a loss of bone maintenance in APP/PS1 model mice

This study shows that Alzheimer's disease and circadian disruption sex- and genotype-specifically reduce bone maintenance in APP/PS1 mice by affecting marrow progenitors and macrophages.

Dual-Approach Co-expression Analysis Framework (D-CAF) Enables Identification of Novel Circadian Regulation From Multi-OmicTimeseries Data

The paper introduces D-CAF, a framework for co-expression analysis of multi-omic time-series data, identifying novel circadian-regulated pathways in mouse macrophages.

Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress

This study investigates how chronic short sleep affects metabolism and survival under oxidative stress in mutants, finding common metabolic defects and suggesting lipid metabolism issues may underlie oxidative stress sensitivity.

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock.

The paper identifies a fuzzy complex formed by negative-arm proteins that regulates the robustness of the circadian clock through electrostatic interactions and conserved motifs.

The PAICE Suite Reveals Circadian Post-Transcriptional Timing of Non-Coding RNAs and Spliceosome Components in Mus musculus Macrophages

The paper introduces the PAICE suite to detect circadian oscillations in RNA and protein data, revealing post-transcriptional regulation and spliceosome timing in mouse macrophages.

Conformational Changes in the Negative Arm of the Circadian Clock Correlate with Dynamic Interactomes Involved in Post-transcriptionally Regulated Processes

The paper investigates conformational changes in circadian clock negative arm proteins and their role in post-transcriptional regulation through dynamic interactomes.

Post-Transcriptional Circadian Regulation in Macrophages Organizes Temporally Distinct Immunometabolic States

The paper shows that circadian regulation in macrophages involves extensive post-transcriptional control of the proteome, influencing metabolic states and immune functions.

MOSAIC: A Joint Modeling Methodology for Combined Circadian and Non-Circadian Analysis of Multi-Omics Data

MOSAIC improves circadian rhythm detection in proteomic data by integrating transcriptomic information, outperforming existing methods and revealing non-circadian trends.

ECHO: an Application for Detection and Analysis of Oscillators Identifies Metabolic Regulation on Genome-Wide Circadian Output

ECHO detects and analyzes oscillators in time-course genome-scale data, revealing metabolic regulation through circadian rhythms with changing amplitudes.