Genetic background influences MAFAS64F-mediated diabetes penetrance in male mice
Zachary A. Loyd, Dongsoo Lee, Mallory A. Maurer, Lizabeth Buzzelli, Jinhua Liu, Garrett Reynolds, Mark P. Keller, Jean‐Philippe Cartailler, Mark A. Magnuson, Roland W. Stein, Jeeyeon Cha
This study shows that genetic background affects disease penetrance in MafAS64F/+ male mice, with C57 background preventing dysglycemia while mixed background leads to diabetes and beta-cell senescence.
bioRxiv · May 20, 2025 · PreprintPhysiology