Dongsoo Lee

This study maps quantitative trait loci modifying glycemia in MafAS64F-driven dysglycemia using genetically diverse mice.

This study shows that genetic background affects disease penetrance in MafAS64F/+ male mice, with C57 background preventing dysglycemia while mixed background leads to diabetes and beta-cell senescence.

The paper introduces scMultiMap, a statistical method to map enhancer-gene associations in single-cell multimodal data, showing improved performance and efficiency in disease-related cell types.