Mark P. Keller

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

The paper maps eQTL, isoQTL, irQTL, and sQTL in DO mice, showing distinct genetic effects on mRNA expression and splicing, and identifies candidate genes and regulatory mechanisms.

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

Glutamine Metabolism Supports α cell Mass and Glucagon Secretion

This study identifies glutaminase as critical for α cell mass and glucagon secretion by linking glutamine metabolism to amino acid sensing and growth.

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

Transcripts with high distal heritability mediate genetic effects on complex metabolic traits

The paper identifies a composite transcriptome signature with high distal heritability that explains 30% of metabolic trait variation across species.

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells

This paper identifies VDAC1 as the target of SW016789, a hypersecretion inducer, and shows it causes distinct transcriptomic changes in beta-cells compared to ER stress.

Genetic background influences MAFAS64F-mediated diabetes penetrance in male mice

This study shows that genetic background affects disease penetrance in MafAS64F/+ male mice, with C57 background preventing dysglycemia while mixed background leads to diabetes and beta-cell senescence.

Modeling metabolic disease susceptibility and resilience in genetically diverse mice

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice

This study identifies genetic loci linking host amylase genes to gut microbiome composition and metabolic traits in hyperlipidemic mice.

Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse population

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin

The paper identifies Abhd2 as an enzyme involved in metabolizing phosphatidylcholine and cardiolipin using genetic and lipidomic data from Diversity Outbred mice.

HNF4a regulates acyl chain remodeling and ether lipid accumulation in hepatic steatosis

This study identifies HNF4a's role in regulating acyl chain remodeling and ether lipid accumulation in hepatic steatosis through cold stress-induced changes in lipid metabolism.

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

The paper identifies three genetic loci influencing mitochondrial proteins and heart hypertrophy in mice using proteomics and association mapping.

QTLViewer: An interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations

QTLViewer provides an interactive webtool for QTL mapping and exploration in CC and DO mouse populations, enhancing accessibility to genetic analysis resources.

A protocol for locating and counting transgenic sequences from laboratory animals using a map-then-capture (MapCap) sequencing workflow: procedure and application of results.

The paper presents a MapCap sequencing workflow to locate and count transgenic sequences in mice, identifying insertion sites and characterizing genetic variations in a diabetes model.

Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice

The paper identifies sample mix-ups and mixtures in microbiome data from Diversity Outbred mice using shotgun sequencing reads.

INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants

INFIMA identifies effector genes of GWAS variants by integrating multi-omics data from mice and applying it to diabetes-associated variants.

Genetic determinants of gut microbiota composition and bile acid profiles in mice

This study identifies genetic loci associated with gut microbiota composition and bile acid profiles in mice using QTL analysis and validation experiments.

Identification of Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets

The paper identifies Slco1a6 as a gene affecting gene expression in mouse pancreatic islets through eQTL analysis and functional studies.