Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I
William W. Fisher, John J. Wright, Man Nok Choy, Guilherme M. Arantes, Robert A. Waddell, Daniel N. Grba, Judy Hirst
The paper presents cryo-EM structures of bovine respiratory complex I under varying protonation conditions, revealing conformational changes at histidine junctions that coordinate proton translocation.
bioRxiv · Aug 17, 2026 · PreprintBiochemistry