Author

Daniel N. Grba

University of CambridgeORCID 0000-0003-2915-951XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Organism:bacteria (other)· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

John J. WrightiD· 2 shared Judy HirstiD· 2 shared William W. FisheriD· 2 shared Alexis HuetiD· 1 shared Alfred A. AntsoniD· 1 shared Dorothy E. D. P. HawkinsiD· 1 shared Guilherme M. ArantesiD· 1 shared Herman K.H. FungiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

John J. WrightORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 17, 2026

Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I

William W. Fisher, John J. Wright, Man Nok Choy…·Judy Hirst

The paper presents cryo-EM structures of bovine respiratory complex I under varying protonation conditions, revealing conformational changes at histidine junctions that coordinate proton translocation.

DOI 10.64898/2026.08.12.744383

cryo-EMexperimental assay

𝕏 PostBluesky

BiochemistrySciencePeer-reviewedJun 13, 2024

Structural basis of a regulatory switch in mammalian complex I

Daniel N. Grba, John J. Wright, Zhan Yin…·Judy Hirst

This study defines the structural basis of a regulatory switch in mammalian complex I by combining cryoEM structures with biochemical analysis, showing how conformational changes mediate deactivation during ischaemia.

32 citations

humancryo-EM

𝕏 PostBluesky

Molecular BiologyNucleic Acids ResearchPeer-reviewedMay 24, 2023

Insights into a viral motor: the structure of the HK97 packaging termination assembly

Dorothy E. D. P. Hawkins, Oliver W. Bayfield, Herman K.H. Fung…·Alfred A. Antson

The paper presents the first structural data of a cos virus DNA packaging motor from bacteriophage HK97, revealing its termination state and asymmetry mechanisms.

32 citationstop 4%

bacteria (other)experimental assay

𝕏 PostBluesky