Author

John J. Wright

University of CambridgeORCID 0000-0001-8987-4449Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Judy HirstiD· 2 shared Robert A. WaddelliD· 2 shared Daniel N. GrbaiD· 1 shared Guilherme M. ArantesiD· 1 shared Harry L. MessentiD· 1 shared Jack H. SalisburyiD· 1 shared Man Nok Choy· 1 shared Marcelo Mesa Costa-LimaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Judy HirstORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 9, 2026

A modular mechanism determines the proton-pumping stoichiometry of respiratory complex I

Robert A. Waddell, Harry L. Messent, Marcelo Mesa Costa-Lima…·Judy Hirst

The paper defines the proton-pumping pathways in respiratory complex I from two bacteria, revealing structural determinants for redox-coupled proton uptake and explaining the stoichiometry adaptation for energy conservation.

DOI 10.64898/2026.10.08.757549

E. colihuman

𝕏 PostBluesky

BiochemistrybioRxivPreprintAug 17, 2026

Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I

William W. Fisher, John J. Wright, Man Nok Choy…·Judy Hirst

The paper presents cryo-EM structures of bovine respiratory complex I under varying protonation conditions, revealing conformational changes at histidine junctions that coordinate proton translocation.

DOI 10.64898/2026.08.12.744383

cryo-EMexperimental assay

𝕏 PostBluesky