Judy Hirst

The paper defines the proton-pumping pathways in respiratory complex I from two bacteria, revealing structural determinants for redox-coupled proton uptake and explaining the stoichiometry adaptation for energy conservation.

The paper presents cryo-EM structures of bovine respiratory complex I under varying protonation conditions, revealing conformational changes at histidine junctions that coordinate proton translocation.

The paper identifies that linear PROTAC scaffolds inhibit mitochondrial complex I, leading to ATP depletion, and proposes structural modifications to mitigate this off-target effect.

The paper presents the structure of respiratory complex I from Paracoccus denitrificans in a turnover-ready state, revealing elements stabilizing the closed state and its relevance to mammalian complex I.

This study shows that mice with reduced respirasomes maintain normal bioenergetics and physiology, suggesting respirasomes are not essential for basic function but may have other roles.