Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology
Chao Ma, Kelsey Campbell, Andrii Kovalenko, Junyan Li, Leslie A. Sandusky‐Beltran, Huimin Liang, Jerry B. Hunt, John Ivan T. Calahatian, Mani Kallupurackal, Shalini Pandey, Muskan Vasisht, Mallory Watler, Zainuddin Quadri, Camilla A. Michalski, Margaret L. Fahnestock, , Daniel C. Lee
This study identifies GPRC6A as a key regulator of mTORC1 signaling and tau pathology in tauopathies, showing that targeting GPRC6A could reduce tau accumulation and related neurodegeneration.
Neurobiology of Disease · Aug 22, 2025Peer-reviewedNeuroscience