Daniel C. Lee

Integration of transcriptional signatures from brain tissue and plasma extracellular vesicles of a preclinical tauopathy mouse model

The paper integrates transcriptomic data from brain tissue and plasma extracellular vesicles in a tauopathy mouse model, identifying shared non-coding RNA signatures that reflect central nervous system changes.

Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

This study identifies GPRC6A as a key regulator of mTORC1 signaling and tau pathology in tauopathies, showing that targeting GPRC6A could reduce tau accumulation and related neurodegeneration.

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

This study investigates how tau pathology affects metabolism and excitatory activity in mouse models, finding that it preserves glucose tolerance and shifts metabolic flux toward glutamate synthesis.

Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status

This study quantifies retinal tau isoforms in early and advanced AD and links them to brain pathology and cognitive status.