The Wild-type and Gain-of-function Mutant p53 Enhance p300 Autoacetylation through Conformational Switching
Stephanie Kaypee, Raka Ghosh, Smitha Asoka Sahadevan, Shilpa Patil, Manidip Shasmal, Piya Ghosh, Neeladri Sekhar Roy, Jayati Sengupta, Siddhartha Roy, Tapas Kumar Kundu
This study shows that p53 enhances p300 autoacetylation through structural changes, which is critical for gene regulation and may be targeted to treat tumors.
bioRxiv · May 4, 2018 · PreprintMolecular Biology