Stephanie Kaypee

This study shows that reduced HOIL-1 activity increases Met1-ubiquitin chains, leading to solid protein aggregates and impaired autophagy in neurodegenerative diseases.

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.

This study shows that p53 enhances p300 autoacetylation through structural changes, which is critical for gene regulation and may be targeted to treat tumors.