Kappa opioid receptor induces epigenetic silencing of brain derived neurotropic factor via HDAC5 in treatment-resistant depression
Anubhav Yadav, Shalini Dogra, Arun kumar Boda, Poonam Kumari, Ajeet Kumar, Manish K. Dash, Prem Narayan Yadav
This study shows that KOR activation reduces BDNF expression in the PFC via HDAC5-mediated epigenetic silencing, contributing to depression-like symptoms in mice.
ACS Chemical Neuroscience · Aug 27, 2024Peer-reviewedNeuroscience