NeuroscienceACS Chemical NeurosciencePeer-reviewed
Kappa opioid receptor induces epigenetic silencing of brain derived neurotropic factor via HDAC5 in treatment-resistant depression
Anubhav Yadav, Shalini Dogra, Arun kumar Boda…·Prem Narayan Yadav
This study shows that KOR activation reduces BDNF expression in the PFC via HDAC5-mediated epigenetic silencing, contributing to depression-like symptoms in mice.
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