Lesion-remote astrocytes govern microglia-mediated white matter repair
Sarah E. McCallum, Keshav B. Suresh, Timothy S. Islam, Manish K. Tripathi, Ann W. Saustad, Oksana Shelest, Aditya Patil, David S. Lee, Brandon Kwon, Katherine Leitholf, Inga Yenokian, Sophia E. Shaka, Connor H. Beveridge, Palak Manchandra, Caitlin E. Randolph, , Joshua E. Burda
This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.
Nature · Dec 17, 2025Peer-reviewedNeuroscience