Gaurav Chopra

The paper shows that sleep in Drosophila allows peripheral hemocytes to clear lipids from the brain, and this process is mediated by the eater receptor.

This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.

This study uses a TBI-on-a-chip model to show that impact injury reduces microglial phagocytosis and alters lipid metabolism, affecting neuroinflammation and neurodegeneration.

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

This study identifies molecular targets and pathways of Pirfenidone's action using neural networks and molecular modeling, revealing its interaction with multiple kinases involved in inflammation and wound healing.

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.

DUBS provides a framework to create standardized benchmarking sets for virtual screening using a simple input format and the Lemon data mining framework.

The paper introduces a Python package for analyzing drug-proteome and drug-disease relationships to predict potential therapeutics.

Lemon provides a fast framework to mine structural features from the PDB by parsing and analyzing 3D biomolecular data efficiently.

This paper introduces a method to functionalize live cell surfaces using native phosphate groups, enabling stable and reversible labeling without prior cell engineering.