Caitlin E. Randolph

Sleep-dependent clearance of brain lipids by peripheral blood cells

The paper shows that sleep in Drosophila allows peripheral hemocytes to clear lipids from the brain, and this process is mediated by the eater receptor.

Lesion-remote astrocytes govern microglia-mediated white matter repair

This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.

Impact Induces Phagocytic Defect in Reactive Microglia

This study uses a TBI-on-a-chip model to show that impact injury reduces microglial phagocytosis and alters lipid metabolism, affecting neuroinflammation and neurodegeneration.

Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.