Author

Manny J Widuch

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Richard W. CarthewiD· 2 shared Cooper W.P. Stringer· 1 shared Hamdi K Kucukengin· 1 shared Kevin G. NybergiD· 1 shared Kyung Je Lee· 1 shared Megan A. Wong· 1 shared Ryder Easterlin· 1 shared Sandra M. Siepka· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 29 mutual co-author links

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2 shared papersSystems Biology

Richard W. CarthewORCID

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2 papers

Recent·Most cited

Insulin Signaling Functions as a Topological Switch That Couples Aging and Heat Stress Responsiveness

Manny J Widuch, Sandra M. Siepka, Richard W. Carthew

This study shows that insulin signaling modulates the genomic response to aging and heat stress by switching between modular and integrated regulatory states in Drosophila.

bioRxiv · Jul 9, 2026 · PreprintSystems Biology

The microprotein Dafcin resembles influenza HA fusion peptide and regulates the size of storage lysosomes in the germline

Kevin G. Nyberg, Ryder Easterlin, Cooper W.P. Stringer, Hamdi K Kucukengin, Manny J Widuch, Kyung Je Lee, Silpol Dhiantravan, Megan A. Wong, Richard W. Carthew

The paper identifies Dafcin, a microprotein in Drosophila, which resembles the influenza HA fusion peptide and regulates yolk granule size by inducing negative membrane curvature.

bioRxiv · Jul 9, 2026 · PreprintCell Biology