Richard W. Carthew

This study shows that insulin signaling modulates the genomic response to aging and heat stress by switching between modular and integrated regulatory states in Drosophila.

The paper identifies Dafcin, a microprotein in Drosophila, which resembles the influenza HA fusion peptide and regulates yolk granule size by inducing negative membrane curvature.

The paper investigates how energy metabolism affects the regulatory impact of activators on gene expression using a mathematical model and experimental validation in Drosophila.

The paper shows that Ds-Fat signaling regulates cell cycle duration scaling with wing size, affecting wing growth rate in Drosophila.

The paper shows that a two-fold change in the Pnt/Yan transcription factor ratio drives photoreceptor fate transitions in Drosophila eye progenitor cells, revealing a mechanism for ultrasensitivity.

The paper analyzes single-cell Senseless protein dynamics in Drosophila to show metastable states during sensory organ fate transition.

This study shows that mechanical forces, not biochemical signals, drive the formation of a regular triangular grid of photoreceptor clusters in the Drosophila eye.

The paper quantifies phenotypic variation in Drosophila wings and identifies a constrained developmental program that integrates genetic and environmental inputs into a single morphological axis.

The paper develops a two-stage marker-assisted pipeline using sgRNA-Cas9 RNPs to improve genome editing efficiency in Drosophila by enabling precise HDR and screening based on eye morphology.

This study shows that Wg and Dpp morphogens regulate gene expression by modulating transcriptional burst frequency in Drosophila.

Fly-QMA automates the analysis of mosaic imaginal discs in Drosophila by segmenting cells, annotating clones, and quantifying gene expression changes.

The paper shows that stochastic gene expression, specifically in senseless protein output, is critical for developmental self-organization in Drosophila, with genomic location and microRNA regulation influencing noise and sensory pattern formation.

The paper shows that layered weak repression synchronizes developmental gene regulation with cellular metabolism, and that reducing metabolism can compensate for loss of repressors.