The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC
Garance Psalmon, Angélique Pipier, Manon Barbotte, Robert H. E. Hudson, Stephen Neidle, David Monchaud
This study shows QN-302 damages DNA at G4 sites in cancer cells and its anticancer effect is enhanced by Olaparib, a DNA repair inhibitor.
bioRxiv · Feb 9, 2026 · PreprintCancer Biology