Author

Angélique Pipier

Centre National de la Recherche ScientifiqueORCID 0000-0002-8481-2860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

David MonchaudiD· 3 shared Jérémie MitteauxiD· 2 shared Bhaskar DattaiD· 1 shared Céline NoirotiD· 1 shared Chinmayee ShuklaiD· 1 shared Dennis GómeziD· 1 shared Éric DefrancqiD· 1 shared Francesco Rota Sperti· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

David MonchaudORCID

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4 papers

Recent·Most cited

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC

Garance Psalmon, Angélique Pipier, Manon Barbotte, Robert H. E. Hudson, Stephen Neidle, David Monchaud

This study shows QN-302 damages DNA at G4 sites in cancer cells and its anticancer effect is enhanced by Olaparib, a DNA repair inhibitor.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

G-quadruplex formation in long non-coding RNAs dysregulated in colorectal cancer

Shubham Sharma, Chinmayee Shukla, Jérémie Mitteaux, Angélique Pipier, Marc Pirrotta, Marie-José Penouilh, David Monchaud, Bhaskar Datta

This study investigates G-quadruplex (G4) formation in three lncRNAs dysregulated in colorectal cancer and shows their stable G4 structures using in silico and in vitro methods.

BMC Biology · Aug 8, 2025Peer-reviewedBiochemistry

The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations

Francesco Rota Sperti, Jérémie Mitteaux, Joanna Zell, Angélique Pipier, Ibai E. Valverde, David Monchaud

The paper introduces two clickable G4 ligands for visualizing and identifying G4s in human cells using click chemistry protocols.

RSC Chemical Biology · Jan 1, 2023Peer-reviewedGenetics

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

Angélique Pipier, Madeleine Bossaert, Jean‐François Riou, Céline Noirot, L-T. Nguyễn, R-F. Serre, Olivier Bouchez, Éric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gómez

The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.

bioRxiv · Feb 18, 2020 · PreprintMolecular Biology