Analysis in vivo using a new method, ARGO (Analysis of Red Green Offset), reveals complexity and cell-type specificity in presynaptic turnover of synaptic vesicle protein Synaptogyrin/SNG-1
Nikita Shiliaev, Manuel A. Alvarez, Ruiling Zhong, Sherlyn Putri Wijaya, Sophie Baumberger, Claire E. Richardson
This paper introduces ARGO, a method to quantify protein turnover in vivo, and uses it to show that Synaptogyrin/SNG-1 partitions into two distinct presynaptic pools with different turnover rates in C. elegans neurons.
Molecular Biology of the Cell · May 20, 2026Peer-reviewedCell Biology