Author

Manuela Rosenfeld

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Jackson Wezeman· 3 shared Matthew Tucker· 3 shared Warren LadigesiD· 3 shared Addison Keely· 2 shared Dan Ratner· 2 shared Gerald Yu LiaoiD· 2 shared Joo Young ParkiD· 2 shared Ruby Mangalindan· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Jackson Wezeman

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3 papers

Recent·Most cited

Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs

Jordan Mazzola, Manuela Rosenfeld, Matthew Tucker, Jackson Wezeman, Warren Ladiges, Gerald Yu Liao

This study shows that GHK-Cu improves cognitive function in aged mice through different molecular mechanisms depending on delivery route and duration.

bioRxiv · Apr 13, 2026 · PreprintPharmacology & Toxicology

Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide

Matthew Tucker, Gerald Yu Liao, Addison Keely, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges

This study shows intranasal GHK-Cu treatment reduces cognitive impairment, amyloid plaques, and inflammation in 5xFAD mice, suggesting potential as an AD therapy.

Aging Pathobiology and Therapeutics · Sep 23, 2024Peer-reviewedNeuroscience

Intranasal GHK peptide enhances resilience to cognitive decline in aging mice

Matthew Tucker, Addison Keely, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Warren Ladiges

This study shows that intranasal GHK-Cu improves cognitive performance and reduces neuroinflammatory and axonal damage markers in aged mice.

bioRxiv · Nov 16, 2023 · PreprintNeuroscience