Author

Jackson Wezeman

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:statistical model· 1

Frequent Co-Authors

Warren LadigesiD· 5 shared Addison Keely· 3 shared Manuela Rosenfeld· 3 shared Matthew Tucker· 3 shared Ruby Mangalindan· 3 shared Dan Ratner· 2 shared Gerald Yu LiaoiD· 2 shared Joo Young ParkiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersNeuroscience

Warren LadigesORCID

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Author profile →

5 papers

Recent·Most cited

Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs

Jordan Mazzola, Manuela Rosenfeld, Matthew Tucker, Jackson Wezeman, Warren Ladiges, Gerald Yu Liao

This study shows that GHK-Cu improves cognitive function in aged mice through different molecular mechanisms depending on delivery route and duration.

bioRxiv · Apr 13, 2026 · PreprintPharmacology & Toxicology

Development of an organotypic brain slice culture model using tissues collected from geriatric mice

Addison Keely, Jackson Wezeman, Savanna Roberts, Sonali Bhana, Warren Ladiges

This study develops an organotypic brain slice culture model from geriatric mice, showing viability and response to stressors, suggesting its potential for aging and neurodegenerative disease research.

bioRxiv · Dec 25, 2025 · PreprintCell Biology

Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide

Matthew Tucker, Gerald Yu Liao, Addison Keely, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges

This study shows intranasal GHK-Cu treatment reduces cognitive impairment, amyloid plaques, and inflammation in 5xFAD mice, suggesting potential as an AD therapy.

Aging Pathobiology and Therapeutics · Sep 23, 2024Peer-reviewedNeuroscience

Intranasal GHK peptide enhances resilience to cognitive decline in aging mice

Matthew Tucker, Addison Keely, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Warren Ladiges

This study shows that intranasal GHK-Cu improves cognitive performance and reduces neuroinflammatory and axonal damage markers in aged mice.

bioRxiv · Nov 16, 2023 · PreprintNeuroscience

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate slows aging in mice

Zhou Jiang, Juan Wang, Denise M. Imai, Timothy A. Snider, Ruby Mangalindan, John Morton, Lida Zhu, Adam B. Salmon, Jackson Wezeman, Jenna J Klug, Jiayi Hu, Vinal Menon, Nicholas A. Marka, Laura Neidernhofer, Warren Ladiges

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.

bioRxiv · Oct 21, 2021 · PreprintSystems Biology