Warren Ladiges

Serum protein profiling reveals hallmark-level aging trajectories and strain-specific resilience in CB6F1J and C57BL/6J male mice.

This paper uses serum protein profiling to identify aging trajectories and strain-specific resilience in mice, revealing pathway-level changes and heterogeneity between strains.

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket.

The paper introduces a Composite Frailty Index (CFI) in house crickets to quantify functional aging and identify gerotherapeutic drugs.

The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.

This study tests intermittent dosing of rapamycin, acarbose, and phenylbutyrate in house crickets, finding lifespan extension and improved locomotion and cognition in some treatments.

Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan

This study shows that house crickets exhibit age-related cognitive decline, including sensory and learning impairments, similar to humans, making them a useful model for studying aging mechanisms.

Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs

This study shows that GHK-Cu improves cognitive function in aged mice through different molecular mechanisms depending on delivery route and duration.

Development of an organotypic brain slice culture model using tissues collected from geriatric mice

This study develops an organotypic brain slice culture model from geriatric mice, showing viability and response to stressors, suggesting its potential for aging and neurodegenerative disease research.

Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies

This study analyzes age- and sex-dependent morphological changes in house crickets, highlighting structural adaptations and environmental factors affecting aging research.

Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice

This study compares age-related decline and behavioral validity in C57BL/6 and CB6F1 mice, finding strain-specific differences in behavior, physiology, and organ pathology.

Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide

This study shows intranasal GHK-Cu treatment reduces cognitive impairment, amyloid plaques, and inflammation in 5xFAD mice, suggesting potential as an AD therapy.

Intranasal GHK peptide enhances resilience to cognitive decline in aging mice

This study shows that intranasal GHK-Cu improves cognitive performance and reduces neuroinflammatory and axonal damage markers in aged mice.

A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways

This study shows a drug cocktail improves cognitive function in aged mice by modulating aging pathways through transcriptomic and molecular analyses.

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate slows aging in mice

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.