RNA binding protein IMP1/ZBP1 drives Actb mRNA localization and local translation in microglial peripheral processes and mediates morphological changes, motility and phagocytosis in response to inflammation
Josune Imaz-Iruretagoyena, Maite Blanco‐Urrejola, Irene Núñez-García, Irene García-Toledo, Luis C. Fernández-Beltrán, Mar Márquez, Silvia Corrochano, Amanda Sierra, Jimena Baleriola
The paper investigates local translation in microglial peripheral processes and shows that IMP1/ZBP1 regulates Actb mRNA localization and translation, affecting microglial morphology and function during inflammation.
bioRxiv · Jul 31, 2023 · PreprintNeuroscience