Irene García-Toledo

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43.

This study characterizes a mouse model with TDP-43 M323K mutation, showing cognitive, motor, and structural brain abnormalities linked to TDP-43 mislocalization and increased levels.

RNA binding protein IMP1/ZBP1 drives Actb mRNA localization and local translation in microglial peripheral processes and mediates morphological changes, motility and phagocytosis in response to inflammation

The paper investigates local translation in microglial peripheral processes and shows that IMP1/ZBP1 regulates Actb mRNA localization and translation, affecting microglial morphology and function during inflammation.

FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations

This study shows that the FUSDelta14 mutation causes neurodevelopmental and systemic metabolic issues in mice, including brain structural abnormalities and metabolic pathway changes.