Amanda Sierra

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

The paper identifies two compounds, trifluoperazine and deoxytubercidin, as novel microglial phagocytosis inhibitors using high-throughput screening and in vivo validation.

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

The paper investigates local translation in microglial peripheral processes and shows that IMP1/ZBP1 regulates Actb mRNA localization and translation, affecting microglial morphology and function during inflammation.

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

The paper shows that depleting microglia and meningeal macrophages delays the onset of EAE by reducing antigen presentation and T cell reactivation.

This study shows that microglial phagocytosis dysfunction in a genetic epilepsy model is linked to local neuronal activity, suggesting a role for neuronal activity in phagocytosis impairment.

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.