Luis C. Fernández-Beltrán

This study characterizes a mouse model with TDP-43 M323K mutation, showing cognitive, motor, and structural brain abnormalities linked to TDP-43 mislocalization and increased levels.

The paper investigates local translation in microglial peripheral processes and shows that IMP1/ZBP1 regulates Actb mRNA localization and translation, affecting microglial morphology and function during inflammation.

This study shows that the FUSDelta14 mutation causes neurodevelopmental and systemic metabolic issues in mice, including brain structural abnormalities and metabolic pathway changes.